A selective pentapeptide ghrelin-receptor agonist, studied for its growth-hormone-secretagogue selectivity profile in pituitary research.
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Ipamorelin is a synthetic pentapeptide developed by Novo Nordisk in the late 1990s as a selective agonist of the growth hormone secretagogue receptor โ the same receptor targeted by the hormone ghrelin. In preclinical studies, it triggers pulsatile growth hormone release from the pituitary that closely mirrors the body's natural secretion pattern, while showing minimal effect on cortisol, prolactin, or ACTH โ a selectivity profile that distinguished it from earlier-generation GH-releasing peptides like GHRP-6. Because of this clean pharmacological profile, it has become a frequently used tool in research on growth-hormone-axis physiology and hypothalamic-pituitary signaling.
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